Guide to Circulease®

Circulease® is a supplement containing a patented blend of nutrients called Fruitflow®. It’s made from the clear gel that surrounds seeds in tomatoes.

Fruitflow® helps improve blood flow through the arteries by keeping blood platelets smoother. Other ingredients in Circulease® include vitamins B1, B2 and B12, which contribute to normal red blood cell formation and heart function.

Dr Sarah Brewer says: ‘The Fruitflow® ingredient in Circulease® helps to support normal formation of red blood cells and maintain normal blood pressure. It also improves blood flow by reducing the spikiness of blood platelets. Its effects on circulatory health are so impressive that it has an approved European Food Standards Agency health claim that Fruitflow ‘Helps maintain normal platelet aggregation, which contributes to healthy blood flow.’

‘Studies have shown the blood platelet-enhancing effects work within an hour and a half of taking the supplement, and this has been shown to last up to 24 hours, after which platelet activity returns to base line.’

What does Circulease® do?

Blood platelets tend to become sticky over time which increases the risk of abnormal blood clotting. Lifestyle factors can make the problem worse, including: smoking; being overweight; stress; eating a high-fat diet; and sitting down for long stretches of time (including on long haul flights). Tomato extract can smooth the blood platelets, so they become less spikey, making it less likely that they will clot together and damage or block arteries.


A number of studies have established that tomato extract can reduce blood platelet stickiness (also known as platelet aggregation). Fruitflow®, the tomato ingredient in Circulease®, works by reducing this stickiness, keeping blood platelets smooth and improving blood flow.

Blood pressure

People with high blood pressure are three times more likely to develop heart disease or suffer a stroke and twice as likely to die from these as people with normal blood pressure. Approximately 62,000 avoidable deaths a year occur in the UK from stroke and heart disease due to poor blood pressure control. There is also increasing evidence high blood pressure is a risk factor for vascular dementia, a type of dementia caused by reduced blood supply to the brain due to diseased blood vessels.

A study by Professor Asim Duttaroy from the University of Oslo, who first discovered Fruitflow®, showed potential for the extract to reduce blood pressure in laboratory tests.

Getting it from your diet

Tomatoes are a great source of nutrients including lycopene, and eating them or drinking tomato juice has beneficial antioxidant effects. But it is the yellow jelly surrounding the tomato seed – not the pulp or the skin – that has the maximum blood platelet-smoothing effect. This is the ingredient used as an extract in Fruitflow® in a Circulease®supplement.

The B vitamins in Circulease® can be found in several foods. Offal, brewer’s yeast, oysters, sardines, eggs, meat and cheese are rich sources of vitamin B12. Vitamin B1 is found in beef, liver, dried milk, nuts, oats, pork, eggs and peas. Vitamin B3 is found in yeast extract, bran, liver, fish, chicken and turkey and peanuts.


There have been no recorded side effects with this product including no increased risk of bleeding for those taking blood-thinning medication. However, if you are allergic or sensitive to tomatoes, it’s best to avoid this supplement. If you are on any medication, do check with your doctor before taking Fruitflow.®

Correct dosage

There is currently no UK Recommended Daily Allowance for Circulease® or Fruitflow®. A typical dose is one tablet a day of Circulease® which contains 150mg of Fruitflow®. Experts recommend Circulease® can be taken with plant sterol supplements to reduce cholesterol.

Nothing beats a healthy, balanced diet to provide all the nutrients we need. But when this isn't possible, supplements can help. This article isn't intended to replace medical advice. Please consult your healthcare professional before trying supplements or herbal medicines.

Studies have shown the blood platelet-enhancing effects work within an hour and a half of taking the supplement, and this has been shown to last up to 24 hours, after which platelet activity returns to base line.

Dr Sarah Brewer


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