As the ovaries run out of eggs, oestrogen levels fall. Oestrogen stimulates the production of collagen, the supportive structure that gives skin its strength and density. The process of skin cell turnover is also directly affected, with lower levels of oestrogen slowing down cell turnover. These factors cause three key changes to skin including a loss of radiance, thinner skin making it more prone to wrinkles, and a loss of moisture making skin much dryer. Natural plant oestrogens in the replenish range mimic the action of natural oestrogen in the skin in turn helping to restore skin.