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Lion’s mane mushroom benefits and how it works

Dr Hilary Jones
Article written by Dr Hilary Jones

Date published 20 August 2025

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The Lion’s Mane mushroom (Hericium erinaceus) has been used in traditional Chinese and Japanese medicine for centuries. Today, it’s becoming increasingly popular in the West for its potential to support mental clarity, focus, memory, and natural energy.

🕒 4 min read

Why Lion’s Mane is Different

For decades, we’ve relied on caffeine in coffee, tea, chocolate, and energy drinks to overcome fatigue and low focus. While caffeine can help temporarily, it can also bring side effects such as palpitations, nausea, and the dreaded energy crash when it wears off.

Lion’s Mane offers a natural alternative. Supported by growing scientific evidence, it helps support mental clarity and focus without the downsides of caffeine.

Healthspan’s Lion’s Mane formulation goes a step further by combining the mushroom with biotin, vitamin B12, and iron — all of which are authorised to support psychological function, cognitive health, and energy metabolism. Learn more about our product here: Healthspan Lion’s Mane.

What Does the Science Say?

  • Cognitive function: A 2009 double-blind, placebo-controlled study in elderly adults with mild cognitive impairment showed that taking 3 g per day of Lion’s Mane powder improved cognitive function after 16 weeks. The benefits faded when the supplement was stopped, suggesting consistent use is important.
  • Nerve growth and brain protection: Animal studies suggest Lion’s Mane stimulates nerve growth factor (NGF) synthesis, a protein vital for nerve cell protection and repair. Other work has shown it may help reduce the buildup of beta-amyloid plaques in the brain, a hallmark of Alzheimer’s disease.
  • Mood and emotional health: A 2010 study in menopausal women found a reduction in anxiety and depressive symptoms after just one month of Lion’s Mane supplementation.
  • Immunity and gut health: In vitro and animal studies also point to potential anti-inflammatory, antioxidant, and immune-supporting effects, along with improvements in gut health.

How Much Should You Take?

Lion’s Mane is generally well tolerated in doses of 1–3 g per day. Most supplements are taken in capsule or powder form.

Healthspan’s Lion’s Mane is enhanced with vitamins and minerals that complement its cognitive benefits. You can also explore vitamin B and vitamin D, both important for brain and nervous system support.

Who is Lion’s Mane For?

Lion’s Mane is a smart supplement for professionals managing busy schedules, students needing focus for study and exams, anyone juggling daily demands and seeking clarity, and older adults interested in supporting long-term brain health.

It is not generally recommended for children, and people with mushroom allergies should avoid it. If you’re pregnant, breastfeeding, or on medication, check with your GP first.

How Long Does It Take to Work?

Some people notice clearer focus and more natural energy within days. In research studies, measurable improvements in cognition often appeared after several weeks of consistent daily intake.

Lion's Mane Clarity & Focus

Lion's Mane Clarity & Focus

Stay sharp and focused

  • 4000 mg Lion’s Mane mushrooms
  • Supports energy and cognitive function
  • With biotin, vitamin B12 and iron
Buy now

You may also see Lion’s Mane written simply as lions mane, especially in informal discussions about its focus, memory and cognitive benefits.

The Takeaway

These days, many of us want to stay mentally sharp without relying on caffeine or artificial stimulants. Lion’s Mane provides a natural option that is well tolerated and supported by promising research.

For those feeling mentally foggy, distracted, or forgetful, Lion’s Mane combined with iron, biotin, and vitamin B12 is well worth considering as part of your daily health routine.

Many mushrooms thrive in the dark, but with Lion’s Mane, you don’t have to.

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Dr Hilary Jones

About Dr Hilary Jones

Dr Hilary Jones is a GP and Medical Advisor to Healthspan, and the patron of several medical charities, including the Meningitis Research Foundation and London's Air Ambulance. He is currently the Health Editor for Good Morning Britain. Dr. Hilary received an MBE in 2020 for "services to broadcasting, public health information and charity."

drhilaryjones.com

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