Jane Collins February 11, 2019

Zinc doesn't get a lot of press, but it's incredibly important for the healthy functioning of many parts of the body - including the immune system. 

There are multiple reasons why your body needs enough zinc. It’s required for protein and DNA synthesis, healthy growth in childhood, fertility, and can also reduce the risk of age-related macular degeneration. 1 2 3 4 5 6 7

Recently, zinc’s importance has been extended to immune function. It is vital in assisting the immune system in its job of fighting off invading bacteria and viruses and is used to reduce symptoms of the common cold – especially a sore throat. Zinc also has protective effects against autoimmune conditions in which the body starts attacking healthy cells.8 9 How exactly can this mineral help to fight autoimmunity, and how much do you need? Here, we take a closer look at zinc in relation to autoimmunity.

What does zinc do?

Zinc is needed to trigger the activation of infection-fighting T cells.10 These control and regulate immune responses and attack infected or unhealthy cells, helping to ward off infection and disease.11 T cell function is highly zinc-dependent and this mineral is needed for their transformation into either ‘killer’ cells or ‘helper/memory’ T cells (which help the immune system to ‘remember’ a given pathogen should it encounter it again).

Zinc also fights infection by subtly reigning in the immune response, to stop it spiralling out of control and causing excessive inflammation in the body.12 It’s suggested this could explain why taking zinc supplements or lozenges at the onset of a cold appears to reduce its symptoms and duration. Zinc also helps to reduce the risk of infection in the elderly, whose immune responses are less efficient, and could play a role in reducing and treating some age-related and/or autoimmune diseases.13

What does a zinc deficiency look like?

If you’re deficient in zinc, this can lead to skin conditions like acne or eczema, eye and skin lesions, slow wound healing, anaemia (by aggravating iron deficiency), diarrhoea and hair loss. Other symptoms include loss of appetite, food cravings for either very salty or very sweet foods, loss of taste sensation, an abnormal or metallic taste in your mouth, and changes to your cognitive health (like impaired memory).14

Chronic (long-term) zinc deficiency can increase production of pro-inflammatory cytokines (chemical messengers in the immune system) and this is implicated in a number of chronic inflammatory and autoimmune conditions including rheumatoid arthritis, multiple sclerosis and type 1 diabetes.15 16 17

How do you increase your zinc intake?

The best way to start upping your zinc intake is with food. Good sources of zinc include beans and pulses, meat, seafood, nuts, sunflower seeds, chickpeas, greens, dairy produce and fortified foods like some breakfast cereals. Typically, most of us get enough from our diet — though it can be difficult to do this if you’re vegetarian (because of the low bioavailability or take up of this nutrient from plant-based sources), or an athlete (due to intense over exercise which increases losses in sweat).

You can also be at risk of low zinc status as a result of excessive drinking and chronic illnesses and conditions in which the body has problems absorbing nutrients including gastrointestinal disorders (also linked to immune deficiency) like coeliac disease, Crohn’s disease, and ulcerative colitis.18

The bottom line: getting more zinc

We need to regularly consume zinc as it’s not naturally stored in the body. A recent report suggested taking just 4mg of extra zinc daily could have a significant effect on improving cellular health and helping to fight infections and disease.19 If you know your diet is not as good as it could be, your first step is to change the foods you eat and to include more zinc-rich meals.

On top of this, you might benefit from taking a daily zinc supplement. These come in a range of forms, including zinc acetate, zinc oxide, zinc citrate, sulphate, gluconate, picolinate, orotate, and chelated zinc. The picolinate and citrate forms have been found to have higher absorption rates.20 If you do opt for a zinc supplement, a typical dose is 15mg per day, based on the EU nutrient reference value or adults. What’s more, the NHS warns against taking any more than 25mg daily — so be sure to keep to the recommended dosage.21

If you’d like to learn more about how to keep your immune system healthy, head on over to our Immunity Advice Centre.


References
1 Zyba, S. J., Shenvi, S. V., Killilea, D. W., et al. (2017). A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations. The American Journal of Clinical Nutrition, 105(02).
2 Age-Related Eye Disease Study Research Group. (2006). A randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss. Archives of Ophthalmology, 119(10).
3 Fallah, A., Mohammad-Hasani, Z., and Colagar, A. H. (2018). Zinc is an Essential Element for Male Fertility: A Review of Zn Roles in Men’s Health, Germination, Sperm Quality, and Fertilization. Journal of Reproduction and Fertility, 19(02).
4
Dumrongwongsiri, O., Suthutvoravut, U., Chatvutinun, S., et al. (2015). Maternal zinc status is associated with breast milk zinc concentration and zinc status in breastfed infants aged 4-6 months. Asia Pacific Journal of Clinical Nutrition, 24(02).
5 Gupta, M., Mahajan, V. K., Mehta, K. S., and Chauhan, P. S. (2014). Zinc Therapy in Dermatology: A Review. Dermatology Research and Practice.
6 Dodig-Curkovic, K., Dovhanj, J., Curkovic, M., et al. (2009). The role of zinc in the treatment of hyperactivity disorder in children. Acta Medica Croatia, 63(04).
7 Yamaguchi, M. (2010). Role of nutritional zinc in the prevention of osteoporosis. Molecular and Cellular Biochemistry, 338(01-02).
8 Haase, H., and Rink, L. (2014). Multiple impacts of zinc on immune function. Metallomics, 06(07).
9 Sanna, A., F, D., Zavattari, P., and Valera, P. (2018). Nutrients, 10(01).
10 Kaltenberg, J., Plum, L. M., Ober-Blobaum, J. L., et al. (2010). Zinc signals promote IL-2-dependent proliferation of T cells. European Journal of Immunology, 40(05).
11 Shankar, A. H., and Prasad, A. S. (1998). Zinc and immune function: the biological basis of altered resistance to infection. The American Journal of Clinical Nutrition, 68(02).
12 Ohio State University. (2013). Zinc helps against infection by tapping breaks in immune response. Science Daily.
13 Prasad, A. S., Beck, F. W., Bao, B., et al. (2007). Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. The American Journal of Clinical Nutrition, 85(03).
14 Mott, D. D. (2011). Unravelling the role of zinc in memory. PNAS, 108(08).
15 Bonaventura, P., Benedetti, G., Albarede, F., and Miossec, P. (2015). Zinc and its role in immunity and inflammation. Autoimmunity Reviews, 14(04).
16 Bredholt, M., and Frederiksen, J. L. (2016). Zinc in Multiple Sclerosis: A Systematic Review and Meta-Analysis.ASN Neuro, 08(03).
17 Valera, P., Zavattari, P., Sanna, A., et al. (2015). Zinc and Other Metals Deficiencies and Risk of Type 1 Diabetes: An Ecological Study in the High Risk Sardinia Island. PLoS One, 10(11).
18 GI Society. (2011). Are You Getting Enough Zinc? GI Society.
19 Zyba, S. J., Shenvi, S. V., Killilea, D. W., et al. (2017). A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations. The American Journal of Clinical Nutrition, 105(02).
20 Wright, M. (2014). Zinc Deficiency, Excess and Supplementation. Patient.
21 NHS. (2017). Others: Vitamins and Minerals. HS UK.

 

Nothing beats a healthy, balanced diet to provide all the nutrients we need. But when this isn't possible, supplements can help. This article isn't intended to replace medical advice. Please consult your healthcare professional before trying supplements or herbal medicines.

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